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Chimeras are three-headed mythological beasts. Each of their heads are of different types of animals such as birds and snakes.
In the episode "Samurai Vac", one of the Chimeras was causing destruction in the city. Samurai Vac tried to fight it off, but Jenny managed to defeat the creature herself. With a seismic kick, Jenny sent the creature flying.
After a while, the same creature managed to return with another much larger Chimera. Jenny was eaten and spat out by the beast, leaving only Samurai Vac to stop the Chimeras. Vac used his vacuum abilities to defeat the creature and banish him from Tokyo forever.