
Slithe (voiced by Bob McFadden in the 1985 series, Dee Bradley Baker in the 2011 series) is the brutish leader of the Reptilians (referred to as Lizards in 2011 series), a race of Lizard Men. Although he lacks sophistication, his intuitive cunning is considerable. Domineering and impatient, Slithe often must browbeat the other Mutants into going along with his plans. Unlike Jackalman and Monkian (whose appearances are identical to other mutants of their kind), Slithe stands out from other Reptilians because of his ears and broader build. He pilots the Nosediver. Slithe served as Rataro's cook earlier in his career, and he retains a discriminating palate.
In the 2011 series, though a descendant of the Lizards that were enslaved by him, Slithe serves Mumm-Ra in order for his kind to take revenge on the Thunderians for generations of persecution. The Lizards have been at war with the Thunderians during their history. Succeeding in ransacking Thundera, Slithe pursues Lion-O's group before overseeing the search for the Book of Omens and later the War Stones. When it came to the attack on the Elephants' village while Mumm-Ra was in the Astral Plane, Slithe and Grune disobey Mumm-Ra's orders and attacked the village. In "Legacy," it was revealed that a Lizard named Rezard (voiced by Rob Paulsen) assisted Leo and Panthera into overthrowing Mumm-Ra. In "New Alliances," some of the Lizards that worked for Slithe have been deserting Mumm-Ra causing Slithe to prosecute any that he catches. Slithe is also instructed by Mumm-Ra to recruit Kaynar and Addicus to Mumm-Ra's services.
He was renamed "Reptílio" in the Spanish version, and "Escamoso" in the Brazilian version.